Welcome to the Illinois Cancer Research Fund (ICRF)
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.
Welcome to the Illinois Cancer Research Fund (ICRF)
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.
Welcome to the Illinois Cancer Research Fund (ICRF)
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.
Our research goal is simple — find answers that help save lives from cancer. Our strategy for funding research is just as straightforward — fund the most innovative cancer research. In fact, we’ve helped make possible many of the major cancer research breakthroughs since 1946.
Our grants fund high impact research conducted by hundreds of promising scientists and health care professionals—primarily early in their careers—at institutions across the United States.
Institution: | Grants: | Amount: |
Loyola University, Chicago | 1 | $789,000 |
Northwestern University | 1 | $792,000 |
Northwestern University, Chicago Campus |
8 | $5,810,200 |
Northwestern University, Evanston Campus |
1 | $792,000 |
University of Chicago | 8 | $4,321,000 |
University of Illinois | 2 | $1,584,000 |
University of Illinois, Chicago | 6 | $7,133,700 |
(grant totals are as of November 3, 2022)
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Welcome to the Illinois Cancer Research Fund (ICRF)
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.
The American Cancer Society (ACS) is the largest private funder of cancer research, having more than $417 million currently invested in grants. With its commitment to beginning researchers, the ACS continues to provide substantial cancer research funding across the United States to scientists in the early stages of their careers, ensuring that many of the best young minds choose careers in cancer research.
The ACS has a goal of funding all exceptional research grants received. Presently, ACS is only able to fund about 50% of the top-ranked research projects approved for funding following peer review. As a result, promising researchers and projects that have the potential to reduce the burden of cancer are put on hold due to budget constraints. The shortfall of funding means that innovative cancer research may not be conducted, and the careers of promising young investigators could be in jeopardy. The COVID-19 pandemic, which has impacted virtually every aspect of cancer care and research, has heightened the need to narrow the gap between the number of ACS grant applications approved for funding and those funded.
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.
In the ICRF's first year (2021), the Fund had raised enough to be able to award it's first Research Scholar Grant in Illinois. The first grant recipient awarded by the newly-formed ICRF was Marc L. Mendillo, PhD, an assistant professor of Biochemistry and Molecular Genetics at Feinberg School of Medicine at Northwestern University’s Chicago Campus. His research project titled the “Role of C16orf72 in Response to Complex and Multifactorial Cancer-Associated Molecular Stresses” is identifying signaling networks and systems that control cell survival in response to specific stresses and understand how they are altered in cancer. An important goal of this work is to use sophisticated molecular approaches to discover novel compounds or drugs that can manipulate these cellular systems and be used to treat cancer. Read more about Dr. Mendillo's research.
Executive Vice President and Chief Financial Officer
Archer Daniels Midland Company
Ray G. Young is executive vice president and chief financial officer of Archer Daniels Midland Company, and a member of the company’s Executive Council. In his role, he oversees the company’s accounting, controlling, treasury, tax, financial planning, and investor relations activities as well as the ADM Investor Services organization. Young is also responsible for strategic oversight of ADM’s business in Asia.
Young joined ADM in 2010 following a 24-year tenure with General Motors Co., during which he held executive leadership positions in finance, general management, planning and operations on four continents. Young served in Shanghai as vice president of GM International Operations, and in 2008 and 2009, he was CFO of General Motors. Between 2004 and 2007, he was the president and managing director of GM do Brasil and Mercosur Operations, based in São Paulo.
Young graduated in 1984 from The Ivey School of Business, University of Western Ontario, in London, Canada, with a bachelor’s degree in business administration. He holds an MBA from the University of Chicago.
Young serves on the boards of directors of International Paper Company, Wilmar International and the U.S.-China Business Council. He is also a member of the board of directors of the American Cancer Society Illinois Division and the CFO Advisory Board of the University of Chicago Booth School of Business.
Principal
Inoca Consulting
Ken Hallman is currently a Principal at Inoca Consulting providing strategy and product management advisory services.
Ken has over 30 years of experience in general management, strategic planning and product management & development. He previously held senior leadership positions at various global companies including Schneider Electric, Motorola/Google, Verizon, Sears Holdings and Verisign. He has led several multi-billion-dollar product families, including the Kenmore brand and the Motorola Droid product family.
John T. Greene joined Discover in September 2019 as executive vice president, chief financial officer. Prior to joining Discover, John served as executive vice president, chief financial officer and treasurer at Bioverativ, a global biopharmaceutical company. From 2014 to 2016, he was chief financial officer for Willis Group Holdings, which was preceded by more than eight years at HSBC Holdings where he held CFO positions for several divisions, including retail bank and wealth management; insurance and consumer and mortgage lending. He also held various CFO roles in his 12-year tenure with General Electric from 1993 to 2005. John holds a bachelor’s degree in accounting from the State University of New York and a master’s degree in Business Administration from the Kellogg School of Management at Northwestern University..
Partner
Swanson, Martin & Bell, LLP
Emily Fitzgerald is a litigation partner at Swanson, Martin & Bell, LLP. Emily serves as national counsel for businesses and corporate clients in state and federal jurisdictions managing commercial litigation, business disputes, business contracts, products liability, and class actions. Emily advises clients in numerous industries, including food and beverage, financial services, insurance, construction, transportation, technology, and healthcare.
Emily graduated with a B.A. from the University of Notre Dame. She received her J.D. from the University of Illinois College of Law.
Assistant Professor, Biochemistry and Molecular Genetics
Northwestern University Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center
A major strategy in anti-cancer efforts is to define the oncogenes that are aberrantly activated in cancers and develop drugs that block their function. Unfortunately, cancer cells often develop resistance to these targeted therapies. Besides oncogenes, cancer cells are often dependent on nonessential cellular factors that become essential in the context of the cancer and drug treatment. Our work thus far has focused on a basic biological question that has broad relevance across cancer biology: why are cancer cells resistant to the harsh stresses that characterize cancer cell growth, the tumor environment, and cytotoxic therapies?
Indeed, cancer cells are known to adapt and survive harsh stress conditions which kill normal cells. These stresses include errors in normal processes, like the building of proteins, that are greatly increased to meet the aggressive growth that characterizes cancer cells. They also include additional challenges, such as those brought on by cytotoxic chemotherapies. These stresses nearly always occur in complex combinations. For example, cancer cells in the core of a solid tumor, have a lower access to oxygen – but they also become nutrient-starved, acid-exposed (because of their unusual metabolism), and inflamed. Identifying factors(s) that help cells tolerate diverse stresses may uncover novel strategies to treat common cancers while suppressing anti-cancer drug resistance.
What powers cancer cell stress resilience? We exposed cancer cells to many stresses and assessed which factors were activated. Next, we developed an algorithm to predict factors important for multi-stress resilience. This revealed a previously unknown factor – the protein known as C16orf72. We confirmed that when cells lose C16orf72, they are less tolerant to many types of stress. C16orf72 seems to help cells use many different coping strategies.
Our preliminary studies suggest that C16orf72 is a key in promoting the extreme stress tolerance of cancer cells. However, we do not yet know how exactly this protein works. By isolating C16orf72 from cells, we found that it binds to a protein called HUWE1. We plan to determine how these proteins cooperate. This should help us translate our findings into therapies. For example, we will map which specific parts of these two proteins interact. By defining this interface, we can design drugs to target it to reduce cancer cell resilience, and restore sensitivity to standard chemotherapies. We will also test the importance of this protein in a mouse model of triple negative breast cancer (TNBC), which in humans is a cancer type typically treated with cytotoxic chemotherapies, and where high levels of C16orf72 are associated with poor prognosis. To do this, we will remove the gene that produces the protein from mouse TNBC cells to test how these modified cancer cells form tumors (in the stressful environment of the animal, as opposed to in cancer cells in the laboratory grown under optimal conditions), and how they respond to a standard chemotherapy in this animal.
In summary, our work will define a new way that cancer cells adapt to stress. The results will set the stage to design novel therapies that will be relevant to all types of cancer.
If you are interested in learning more about the Illinois Cancer Research Fund , contact the American Cancer Society at ICRF@cancer.org.
Welcome to the Illinois Cancer Research Fund (ICRF)
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.
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The American Cancer Society conducts long-term studies that help us better understand the causes of cancer and how to prevent the disease. These studies have shown how lifestyle, environmental, genetic and other factors relate to cancer risk and how they ultimately played a role in the 29% drop in cancer death rates between 1991 and 2017.
The American Cancer Society funds scientists who conduct research about cancer at medical schools, universities, research institutes, and hospitals throughout the United States. We use a rigorous and independent peer review process to select the most innovative research projects proposals to fund. To-date, the Society has invested more than $300 million, funding 550 grants. Initial investigations focused on gathering data to document that health inequities exist; then studies moved to identifying the multi-factorial causes; since 2013, the focus has been on solution-based strategies.
current funding totals as of August 1, 2021
The American Cancer Society awarded over $16 million in grants to establish Cancer Health Equity Research Centers (CHERC) at Minority Serving Institutions (MSIs) in 2022.
The inaugural cohort of institutions includes the Arizona Board of Regents – University of Arizona; the University of Illinois at Chicago; Morehouse School of Medicine and Howard University. Each institution received a four-year grant of $4.08 million.
The institutions selected in the initial cohort will implement solution-based research addressing cancer health disparities that will contribute to achieving health equity and reducing cancer mortality.
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University of Kentucky Diversity in Cancer Research Internship Recipients from 2021. |
Diverse perspectives in research are an essential component of driving innovative problem-solving that accelerates new approaches to the prevention and treatment of cancer. To improve diversity in the field of cancer research, the American Cancer Society launched a new grant program awarding funding to universities to implement its Diversity in Cancer Research (DICR) Internship program.
Made possible by a $5 million grant from the Elizabeth and Phil Gross Family, the American Cancer Society DICR pilot launched in 2021 with 32 interns at Emory University, Georgetown University, the University of Chicago, the University of Colorado, the University of Kentucky, the University of Maryland, the University of New Mexico, and Washington University. The goal of the DICR Internship program is to enroll 100 interns per year over ten years.
In 2022, 12 universities are receiving DICR Internship grants, including: Yale University School of Medicine; Emory University; Case Western Reserve University; the University of Chicago; Indiana University; University of Kentucky Research Foundation; University of Colorado Denver Anschutz Medical Campus; University of New Mexico Health Sciences Center; Georgetown University; Board of Regents of the University of Oklahoma Health Sciences Center; University of Maryland, Baltimore; and Washington University in St. Louis. |
The success of the American Cancer Society grant program is exemplified by the fact that 50 American Cancer Society-funded researchers have received a Nobel Prize for their work. |
Carolyn Bertozzi, PhD, was one of three scientists to be awarded the 2022 Nobel Prize in Chemistry for the development of click chemistry and bio-orthogonal chemistry. She is the 50th American Cancer Society-funded researcher and the first woman researcher funded by ACS to win the prestigious honor. Learn more about her work. |
The American Cancer Society Cancer Action Network (ACS CAN) is the nonprofit, nonpartisan advocacy affiliate of the American Cancer Society. Its role is to support evidence-based policy and legislative solutions designed to eliminate cancer as a major health problem. American Cancer Society (ACS) researchers collaborate with ACS CAN staff to explore how and why certain groups of people in the US are not benefitting from health care services such as cancer prevention, early detection, and treatment.
ACS CAN is attacking disparities by changing or adding new evidence-based public health policies at the local, state, and federal levels. The goal of ACS CAN is to reduce these disparities and improve health outcomes for all US population groups regardless of race, ethnicity, gender, age, sexual orientation, socioeconomic status, or zip code.
Welcome to the Illinois Cancer Research Fund (ICRF)
The ACS Illinois Area Board created the Illinois Cancer Research Fund (ICRF) with the goal of having all approved research projects led by investigators at Illinois-based institutions funded.